可以是一种综合形式的thc解决睡眠呼吸暂停？
The search for睡眠呼吸暂停的医疗治疗不涉及使用CPAP面膜的使用。许多患者发现CPAP面具繁琐，并且宁愿放弃它们并面对（严重）后果。使用口头设备并没有被证明具有重要帮助，并且它们可能是非常昂贵的。
关于睡眠呼吸睡眠治疗的新研究发表了睡眠呼吸暂停的良好重视。一种December 2017 study最新治疗涉及一种相当争议的药用药剂：在西北大学进行的研究进行了测试Dronabinol., a synthetic version of delta-9-tetrahydrocannabinol or THC, which is the compound responsible for the euphoric effects of marijuana.
研究：Dronabinol是否有助于治疗睡眠呼吸暂停？
该研究涉及诊断出56名患者，被诊断出患有严重阻塞性睡眠呼吸暂停（OSA），如呼吸暂停次乳酸的呼吸暂停指数（AHI）为大于30.这些患者也有过度的白天嗜睡，如异常测量Epworth Sleepiness Scale（ESS）。建立基线测量，并在12周后，研究人员将Dronabinol的用剂量与2.5和10毫克的剂量进行比较。与安慰剂的受试者相比，研究人员注意到受试者的AHI显着减少了受试者的AHI和赋予药物的科目中的ESS。
This research was part of what is known as the Pharmacotherapy of Apnea by Cannabimimetic Enhancement (PACE) trial phase 2. This trial offered the basis for approaching the FDA to gain approval for a phase 3 trial that will lead to approval dronabinol’s use for sleep apnea. The drug is currently approved for the treatment of eating disorders associated with AIDS and for chemotherapy-induced nausea.
Dronabinol适用于2.5mg，5毫克和10毫克片剂。它被认为是“时间表III药物”，这意味着它具有较低的滥用可能性，但它仍然被美国毒品执法机构（DEA）监测，其使用受限制刚才提到的两种指示。尽管2阶段发现，它不能像其他药物一样使用“Off标签”。它以品牌名称玛丽诺销售。
Does this mean marijuana can be used to help sleep apnea?
虽然Dronabinol，一种四氢甘油醛的合成形式，大麻的活性成分，由FDA批准特定适应症，这并不意味着大麻已被批准用于治疗用途。It is unlikely that any “plant” can be approved as a medicinal treatment. The FDA approval process is contingent on reproducibility of the specific agent that’s responsible for its effect. We can’t really do that when it comes to a plant. Additionally, a synthetic compound can be monitored for purity of composition, whereas a plant when ingested or smoked contains numerous unaccounted-for ingredients.
DEA已确定烟熏大麻可以含有超过400种不同的化学品，包括在香烟烟雾中发现的一些危险的化学品。这正是为什么我们不能认为大麻可以提供相同的治疗益处或安全性，无论是治疗恶心或阻塞性睡眠呼吸暂停。
这些结果是什么意思睡眠呼吸暂停的人？
目前的标准治疗OSA通过具有正面压力面罩（CPAP）的机械方法，以在仰卧睡眠期间保持露天通道。本研究探讨了影响大脑的药物可能作用的可能性，帮助促进调节上气道的肌肉以维持开放的气道。
坚持CPAP.has had its problems including the noise it creates while in operation and discomfort when wearing the mask. Patients also often feel that the problem has been “cured” after CPAP is used for a certain duration of time. The possibility of医学治疗病情with the use of a pill may have strong allure, especially among patients diagnosed with the disease who don’t feel any profound symptoms. Those individuals are especially resistant to using CPAP therapy.
Findings from this study go beyond just the improvement in the patency of the airway from Marinol. Although the primary endpoints measured were improvements in the AHI, the secondary endpoints also showed improvements. Those include the improvements in the ESS (as previously mentioned), which measures a person’s subjective perception of daytime sleepiness, and improvements in the Maintenance of Wakefulness Test. This test measures the ability to stay awake during traditional waking hours. The study also measured the time it took to see a drop in the oxygen saturation of the blood and the perception of treatment satisfaction. It rated positively in all these measures.
It’s possible that the effect of dronabinol goes farther than improving the quality of sleep by avoiding obstruction of airways. It may be that dronabinol also has an intrinsic effect on the brain, improving the quality of sleep through other pathways. These are important considerations because they suggest impact of the drug on several parts of the brain.
显然，需要更多的研究来探讨Dronabinol的治疗作用，看看它是否可用于治疗其他与睡眠相关的条件。
